TILT Biotherapeutics

TILT Biotherapeutics.

Bioanalysis of Biotherapeutics

Volume 4 • Issue 4 • 1000e116 J Anal Bioanal Tech ISSN:2155-9872 JABT, an open access journal Obtaining relevant and accurate information on pharmacokinetics (PK) and exposure for biotherapeutics is one of the key fundamental elements in research and development (R&D) process. Typical R&D process if often described in several steps starting with discovery phase continuing through several develo...

Polymeric multilayer capsules delivering biotherapeutics.

Polymeric multilayer capsules have emerged as a novel drug delivery platform. These capsules are fabricated through layer-by-layer sequential deposition of polymers onto a sacrificial core template followed by the decomposition of this core yielding hollow capsules. The resulting nanometer thin membrane is permselective, allowing diffusion of water and ions but excluding larger molecules. Moreo...

Pediatric Dosing and Body Size in Biotherapeutics

Although pediatric doses for biotherapeutics are often based on patients' body weight (mg/kg) or body surface area (mg/m²), linear body size dose adjustment is highly empirical. Growth and maturity are also important factors that affect the absorption, distribution, metabolism and excretion (ADME) of biologics in pediatrics. The complexity of the factors involved in pediatric pharmacokinetics l...

Advances in the Development of Biotherapeutics

1 Institut Pasteur, Microbial Evolutionary Genomics, Département Génomes et Génétique, Paris, France 2CNRS, UMR3525, Paris, France 3Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria 4enGenes Biotech GmbH, Vienna, Austria 5Instituto de Biologia Experimental e Tecnológica, Apartado 12, Oeiras, Portugal 6Instituto de Tecnologia Quı́mica e Biológica, Uni...